NIH-supported postdoc fellows in Leukocyte Biology an d Immunology at the University of Connecticut School of Medicine （UConn Health）

Our laboratory is looking for multiple motivated postdoctoral fellows to study integrin activation an d leukocyte trafficking in inflammatory diseases using advanced microscopy, such as super-resolution microscopy, high-resolution live-cell imaging, an d intravital microscopy. Our current research directions include:

1. The auto-inhibitory in-cis interaction of integrin an d their ligands.

2. The roles an d mechanism of integrin activation an d clustering using super-resolution microscopy.

3. Pharmacology test of drugs targeting integrins in vitro an d in disease models （myocardial ischemia-reperfusion injury）

4. High-throughput screening of drugs inhibiting integrin activation an d inflammation.

5. Monitoring of leukocyte dynamics in diseases using intravital microscopy an d in vivo flow cytometry （IVFC）.

We work on primary human leukocytes, leukocyte-like cell lines, an d gene-edited mice to answer questions regarding integrin activation an d leukocyte trafficking. Multiple advanced microscopy, from single-molecular level super-resolution microscopy to physiological-relevant intravital microscopy, will be used.

The PI is a faculty member （https://facultydirectory.uchc.edu/profile?profileId=Fan-Zhichao） of the Department of Immunology at UConn Health （https://health.uconn.edu/immunology/）. This is an exciting research environment to cultivate new research ideas an d opportunities. The PI has received an R01 award from NIH an d a startup fund from UConn Health to support our research. The candidate will receive excellent guidance on scientific research as well as career development （grants, awards, conferences, etc.）.

Qualified applicants should have a Ph.D. degree in Cell Biology, Immunology, Biomedical Engineering, Cardiology, Ｏr in a related field, an d have a strong record of publications. Prevalence will be given to candidates with experience in gene-editing in cells an d mice, live-cell imaging, super-resolution imaging, Ｏr intravital imaging. People with disease models in mice, such as myocardial ischemia-reperfusion injury, are encouraged to apply. Interested candidates should send their CV, representative publications, an d names of three references to Dr. Zhichao Fan （zfan@uchc.edu）.